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長庚科技大學食品暨化妝品安全研究中心
中心主任-鮑力恒

鮑力恒 Li-Heng Pao

職稱:教授

 

主要學歷:美國密西根大學藥學院博士

分機號碼: 5111

電子郵件帳號: paolh@mail.cgust.edu.tw

研究專長:藥物動力學、生物藥劑學

研究室:食品安全檢驗室

研究概要:

本研究室的主要工作是利用藥物動力學與生物藥劑的原理進行為藥物相關劑型設計、評估與開發,以期能與臨床實務與產業之應用相結合。此外也持續結合新的科技與技術來解決民生產業科技之實際需求。如結合基因變異與藥物動力學進行病患用藥之調整;以代謝質體學進行相關疾病治療生物標記之研究與開發;針對國人之使用中藥之普遍性進行中西藥物交互作用之評估;同時有針對中藥對腎臟功能影響進行一系列之評估,以期能對國人用藥安全上盡一分心力。

研究方向:

本研究室主要研究領域為 (1) 藥物於生物基質中分析分法開發;(2) 藥物基因動力學於臨床上之應用;(3) 中西藥物交物作用之評估;(4) 中藥對腎臟功能之影響評估;(5) 代謝質體學於疾病治療與生物標誌開發之應用。

最近研究之主題:

1. 常用中藥製劑(科學中藥)與西藥之交互作用之評估。

2. 中藥製劑對腎臟功能影響之評估。

3. 中藥對於神經保護與再生之開發與研究。

4. 代謝質體學(metabolomics)於藥物治療與生物標記開發之研究。

5. 藥物分析方法之開發

論文著作 2008-迄今):

1.   Li, W-Y, Pao, L-H*, Pan, R-N and Ni, S-J. Substitution treatment for opioids dependence- methadone. Taiwan Police College Bulletin. 4(4): 23-33, 2008

2.   Kuo, C-W. Liaw, W-J. Huang, P-W and Pao, L-H.* A rapid and sensitive HPLC method for determination of roxatidine in human plasma. J Food Drug Anal. 16(3): 1-5, 2008 (IF: 0.643)

3.   Pan, R-N. Lin, C-C. Huang, P-W. Hsiong, C-H and Pao, L-H.* Simultaneous determination of triazolam and its metabolites in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B. 872: 58-62, 2008. doi:10.1016/j.jchromb.2008.07.014. (IF: 2.888)

4.   Young, T-H. Tang, H-S. Chao, Y-C. Lee, H-S. Hsiong, C-H. Pao, L-H and Hu, O Y-P. Quantitative rat liver function test by galactose single point method. LAB ANIM. 42: 495–504, 2008. DOI: 10.1258/la.2007.06040e. (IF:1.209) 

5.   Pan, R-N. Chian, P-S. Liu, C-H. Kou, B. P-C and Pao, L-H.* Determination of memantine in human plasma by liquid chromatography- tandem mass Spectrometry method: Application to a pharmacokinetic study. Chromatographia, 70: 783-788, 2009. DOI: 10.1365/s10337-009-1231-8. (IF:1.195)

6.   Pao, L-H.* Jian, C-S. Pan,R-N. Hsiong, C-H. Huang, P-W and Tsai, W-S. Stability of 11-nor-delta-9- tetrahydrocannabinol-9-carboxylic acid from urine samples stored in polypropylene, polyethylene and polystyrene containers at different temperatures. Taiwan Pharm J, 61: 23-33, 2009.

7.   Pao, L-H.* Chi, J-F and Hu O Y-P. Drug and the Pharmaceutical Sciences, Volume 201. Chapter 10. Taiwan Requirements for Generic Drug Registration. In Generic Drug product Development: International Regulatory Requirements. 2010.

8.   Fan, S-Y. Lin, C-C and Pao, L-H.* Determination of p-aminohippuric acid in rat plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B, 878: 1643-1646, 2010. DOI:10.1016/j.jchromb.2010.04.015 (IF: 2.888)

9.   Lin, C-C. Kuo, C-W. and Pao, L-H*. Development and validation of a liquid chromatography-tandem mass spectrometry       method for simultaneous quantification of p-aminohippuric acid and inulin in rat plasma for renal function study. Anal Bioanal Chem. 398(2): 857-865, 2010. (IF: 3.778)

10.    Pan, R-N. Hsiong, C-H. Huang, P-W and Tsai, W-S. Lee W-Y and Pao, L-H.*   Simultaneous quantification of triazolam and its metabolites in human urine by liquid chromatography- tandem mass Spectrometry. J Anal Toxicol35(3): 170-5, 2011 (IF:2.022)

11.    Chiang, T-Y, Pao, L-H, Hsiong, C-H. Huang, P-W, Lin K-W and Hu, Oliver Y-P. Simultaneous determination of buprenorphine, norbuprenorphine and naloxone in human plasma by LC-MS-MS. Chromatographia, 74: 575-583, 2011. DOI: 10.1007/s10337-011-2095-2, DOI 10.1007/s00216-010-3957-4. (IF:1.195)

12.    Pan, R-N. Kuo, B P-C and Pao L-H.* Validated LC-MS-MS method for the determination of quetiapine in human plasma: Application to a pharmacokinetic study. J Chromatogr Sci, 50:277-282, 2012. DOI: 10.1093/Chromsci/Bms001. (IF: 0.884)

13.   Chang, Y-L. Cheng Y-C. Jou, S-F and Pao, L-H.* Clinical efficacy evaluation and therapeutic monitoring of vancomycin: from pharmacodynamics and pharmacokinetics points of view. Formosan J Med, 16(3):326-331, 2012.

14.    Pao, L-H.* Hu, O Y-P. Fan, H-Y. Lin, C-C. Liu, L-C and Huang, P-W. Herb-drug interaction of 50 single-herbal preparations on CYP3A4 activity in vitro and in vivo. Am J Chinese Med. 40(1): 57-73, 2012. DOI: 10.1142/S0192415X1250005X. (IF: 1.979)

15.    Lin, C-C. Fan, H-Y. Kuo, C-W and Pao, L-H.*. Evaluation of Chinese herbal medicine induced herb-drug interactions: focusing on organic anion transporter 1. Evid-based Complement Altern Med. Volume (2012), Article ID 967182, 12 pages. DOI: 10.1155/2012/967182 (IF:4.774)

16.    Pao L-H.* Lu, S-W. SunG-G. Chiou S-H and Ma K-S. Three Chinese herbal medicines promote neuroproliferation in vitro, and reverse the effects of chronic mild stress on behavior, the HPA axis, and proliferation of hippocampal precursor cell in vivo. J Ethnopharm. 144: 261-269, 2012. (IF:3.014)

17.      Lee, J-T. Pao, L-H. Lee, M-S. Liao, J-W. Shih, C-M. Hsiong, C-H. Yin, F-Y. Shih, T-Y and Hu, O Y-P.. A new approach to facilitate diagnosis of nonalcoholic fatty liver disease through a galactose single point method. Dig Liver Dis. 45: 134-141, 2013. (IF:3.054))

18.    Lee, J-T. Pao, L-H. Hsiong, C-H. Huang, P-W. Shih, T-Y and Hu, O Y-P. Validated liquid chromatography–tandem mass spectrometry method for determination of totally nine probe metabolites of cytochrome P450 enzymes and UDP-glucuronosyltransferases. Talanta, 106: 220-228, 2013; .doi.org/10.1016/j.talanta.2012.12.023. (IF:3.794)

19.    Chao, Jung, Liao, J-W. Peng,W-H. Lee, M-S. Pao, L-H and Cheng H-Y. Antioxidant, Analgesic, Anti-Inflammatory, and Hepatoprotective Effects of the Ethanol Extract of Mahonia oiwakensis Stem. Int J Mol Sci. 201314, 2928-2945; doi:10.3390/ijms14022928  (IF:2.598)

20.    Huang,P-W. Liu, H-T, Hsiong, C-H. Pao, L-H. Lu,C-C. Ho S-T and Hu, O Y-P. Simultaneous determination of nalbuphine and its prodrug sebacoly dinalbuphine ester in human plasma by ultra-performance liquid chromatography – tandem mass spectrometry and its application to pharmacokinetic study in humans. Biomed Chromatogr. 2013, DOI 10.1002/bmc.2867 (IF:1.996)

21.    Young, T-H. Shih, T-Y. Lee, H-S. Hsiong, C-H. Pao, L-H and Hu O Y-P. Protective effects of disulfiram against isoniazid induced hepatotoxicity. J Pharmacol Exp Ther. (Revised), 2013. (IF:3.828)

22.    Chao J, Huo T-I, Chang Y-L, Cheng H-Y, Tsai J-C, Liao Ji-W, Lee M-Sh, Qin X-i, Pao L-H*, Peng W-H*. Metabolomic Assessment of the Protective Effect of Gallic acid on High Fat Diet-induced Hepatosteatosis in mice" (revised) Plos one. (2013)

*Corresponding author