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鮑力恒 Li-Heng Pao




分機號碼: 5111







本研究室主要研究領域為 (1) 藥物於生物基質中分析分法開發;(2) 藥物基因動力學於臨床上之應用;(3) 中西藥物交物作用之評估;(4) 中藥對腎臟功能之影響評估;(5) 代謝質體學於疾病治療與生物標誌開發之應用。


1. 常用中藥製劑(科學中藥)與西藥之交互作用之評估。

2. 中藥製劑對腎臟功能影響之評估。

3. 中藥對於神經保護與再生之開發與研究。

4. 代謝質體學(metabolomics)於藥物治療與生物標記開發之研究。

5. 藥物分析方法之開發

論文著作 2008-迄今):

1.   Li, W-Y, Pao, L-H*, Pan, R-N and Ni, S-J. Substitution treatment for opioids dependence- methadone. Taiwan Police College Bulletin. 4(4): 23-33, 2008

2.   Kuo, C-W. Liaw, W-J. Huang, P-W and Pao, L-H.* A rapid and sensitive HPLC method for determination of roxatidine in human plasma. J Food Drug Anal. 16(3): 1-5, 2008 (IF: 0.643)

3.   Pan, R-N. Lin, C-C. Huang, P-W. Hsiong, C-H and Pao, L-H.* Simultaneous determination of triazolam and its metabolites in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B. 872: 58-62, 2008. doi:10.1016/j.jchromb.2008.07.014. (IF: 2.888)

4.   Young, T-H. Tang, H-S. Chao, Y-C. Lee, H-S. Hsiong, C-H. Pao, L-H and Hu, O Y-P. Quantitative rat liver function test by galactose single point method. LAB ANIM. 42: 495–504, 2008. DOI: 10.1258/la.2007.06040e. (IF:1.209) 

5.   Pan, R-N. Chian, P-S. Liu, C-H. Kou, B. P-C and Pao, L-H.* Determination of memantine in human plasma by liquid chromatography- tandem mass Spectrometry method: Application to a pharmacokinetic study. Chromatographia, 70: 783-788, 2009. DOI: 10.1365/s10337-009-1231-8. (IF:1.195)

6.   Pao, L-H.* Jian, C-S. Pan,R-N. Hsiong, C-H. Huang, P-W and Tsai, W-S. Stability of 11-nor-delta-9- tetrahydrocannabinol-9-carboxylic acid from urine samples stored in polypropylene, polyethylene and polystyrene containers at different temperatures. Taiwan Pharm J, 61: 23-33, 2009.

7.   Pao, L-H.* Chi, J-F and Hu O Y-P. Drug and the Pharmaceutical Sciences, Volume 201. Chapter 10. Taiwan Requirements for Generic Drug Registration. In Generic Drug product Development: International Regulatory Requirements. 2010.

8.   Fan, S-Y. Lin, C-C and Pao, L-H.* Determination of p-aminohippuric acid in rat plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B, 878: 1643-1646, 2010. DOI:10.1016/j.jchromb.2010.04.015 (IF: 2.888)

9.   Lin, C-C. Kuo, C-W. and Pao, L-H*. Development and validation of a liquid chromatography-tandem mass spectrometry       method for simultaneous quantification of p-aminohippuric acid and inulin in rat plasma for renal function study. Anal Bioanal Chem. 398(2): 857-865, 2010. (IF: 3.778)

10.    Pan, R-N. Hsiong, C-H. Huang, P-W and Tsai, W-S. Lee W-Y and Pao, L-H.*   Simultaneous quantification of triazolam and its metabolites in human urine by liquid chromatography- tandem mass Spectrometry. J Anal Toxicol35(3): 170-5, 2011 (IF:2.022)

11.    Chiang, T-Y, Pao, L-H, Hsiong, C-H. Huang, P-W, Lin K-W and Hu, Oliver Y-P. Simultaneous determination of buprenorphine, norbuprenorphine and naloxone in human plasma by LC-MS-MS. Chromatographia, 74: 575-583, 2011. DOI: 10.1007/s10337-011-2095-2, DOI 10.1007/s00216-010-3957-4. (IF:1.195)

12.    Pan, R-N. Kuo, B P-C and Pao L-H.* Validated LC-MS-MS method for the determination of quetiapine in human plasma: Application to a pharmacokinetic study. J Chromatogr Sci, 50:277-282, 2012. DOI: 10.1093/Chromsci/Bms001. (IF: 0.884)

13.   Chang, Y-L. Cheng Y-C. Jou, S-F and Pao, L-H.* Clinical efficacy evaluation and therapeutic monitoring of vancomycin: from pharmacodynamics and pharmacokinetics points of view. Formosan J Med, 16(3):326-331, 2012.

14.    Pao, L-H.* Hu, O Y-P. Fan, H-Y. Lin, C-C. Liu, L-C and Huang, P-W. Herb-drug interaction of 50 single-herbal preparations on CYP3A4 activity in vitro and in vivo. Am J Chinese Med. 40(1): 57-73, 2012. DOI: 10.1142/S0192415X1250005X. (IF: 1.979)

15.    Lin, C-C. Fan, H-Y. Kuo, C-W and Pao, L-H.*. Evaluation of Chinese herbal medicine induced herb-drug interactions: focusing on organic anion transporter 1. Evid-based Complement Altern Med. Volume (2012), Article ID 967182, 12 pages. DOI: 10.1155/2012/967182 (IF:4.774)

16.    Pao L-H.* Lu, S-W. SunG-G. Chiou S-H and Ma K-S. Three Chinese herbal medicines promote neuroproliferation in vitro, and reverse the effects of chronic mild stress on behavior, the HPA axis, and proliferation of hippocampal precursor cell in vivo. J Ethnopharm. 144: 261-269, 2012. (IF:3.014)

17.      Lee, J-T. Pao, L-H. Lee, M-S. Liao, J-W. Shih, C-M. Hsiong, C-H. Yin, F-Y. Shih, T-Y and Hu, O Y-P.. A new approach to facilitate diagnosis of nonalcoholic fatty liver disease through a galactose single point method. Dig Liver Dis. 45: 134-141, 2013. (IF:3.054))

18.    Lee, J-T. Pao, L-H. Hsiong, C-H. Huang, P-W. Shih, T-Y and Hu, O Y-P. Validated liquid chromatography–tandem mass spectrometry method for determination of totally nine probe metabolites of cytochrome P450 enzymes and UDP-glucuronosyltransferases. Talanta, 106: 220-228, 2013; (IF:3.794)

19.    Chao, Jung, Liao, J-W. Peng,W-H. Lee, M-S. Pao, L-H and Cheng H-Y. Antioxidant, Analgesic, Anti-Inflammatory, and Hepatoprotective Effects of the Ethanol Extract of Mahonia oiwakensis Stem. Int J Mol Sci. 201314, 2928-2945; doi:10.3390/ijms14022928  (IF:2.598)

20.    Huang,P-W. Liu, H-T, Hsiong, C-H. Pao, L-H. Lu,C-C. Ho S-T and Hu, O Y-P. Simultaneous determination of nalbuphine and its prodrug sebacoly dinalbuphine ester in human plasma by ultra-performance liquid chromatography – tandem mass spectrometry and its application to pharmacokinetic study in humans. Biomed Chromatogr. 2013, DOI 10.1002/bmc.2867 (IF:1.996)

21.    Young, T-H. Shih, T-Y. Lee, H-S. Hsiong, C-H. Pao, L-H and Hu O Y-P. Protective effects of disulfiram against isoniazid induced hepatotoxicity. J Pharmacol Exp Ther. (Revised), 2013. (IF:3.828)

22.    Chao J, Huo T-I, Chang Y-L, Cheng H-Y, Tsai J-C, Liao Ji-W, Lee M-Sh, Qin X-i, Pao L-H*, Peng W-H*. Metabolomic Assessment of the Protective Effect of Gallic acid on High Fat Diet-induced Hepatosteatosis in mice" (revised) Plos one. (2013)

*Corresponding author