Changbai Mountain Ginseng (Panax ginseng CA Mey) Extract Supplementation Improves Exercise Performance and Energy Utilization and Decreases Fatigue-Associated Parameters in Mice
圖文摘要說明
這張圖片以流程圖的形式總結了一項關於長白山人參 (CMG) 對小鼠運動表現和抗疲勞作用的研究。圖的左上角展示了人參皂苷 Ro的化學結構，這是 CMG 提取物的主要成分。左側呈現了長白山人參的實物照片，以及研究中對 8 週大的雄性 ICR 小鼠進行為期 4 週的口服 CMG 乙醇提取物補充（0、5、25 mg/kg/天，分別對應載體組、CMG-1X 組和 CMG-5X 組）的過程。 流程圖的中間部分展示了 CMG 的作用效果。首先，CMG 提取物增加了小鼠的**肌肉力量**（前肢握力增加），接著提高了耐力游泳時間。在 15 分鐘的游泳運動後，與對照組相比，CMG 組小鼠的血清乳酸、氨、肌酸激酶 (CK)和血尿素氮 (BUN)水平降低，而葡萄糖水平則得到節省。此外，CMG 還能調節肌肉糖原儲存，促進糖原合成並減少糖原分解，從而增加肌肉糖原含量，為運動提供重要的能量來源。 總體而言，該圖說明 CMG 提取物通過增加肌肉質量、提高運動表現和能量利用率，以及減少與疲勞相關的生化指標，在體內展現出抗疲勞和促運動能力的潛在作用。研究結果表明，CMG 的主要成分人參皂苷 Ro 可能作為食品工業中潛在的促運動補充劑成分。
Abstract
Changbai Mountain Ginseng (CMG, Panax ginseng C.A. Mey) is a traditional medicine commonly found in Northeast China and grows at elevations of 2000 m or higher in the Changbai Mountain Range. CMG, considered to be a "buried treasure medicine", is priced higher than other types of ginseng. However, few studies have demonstrated the effects of CMG supplementation on exercise performance, physical fatigue, and the biochemical profile. The major compound of CMG extract was characterized by electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Male ICR mice were divided into 3 groups, the vehicle, CMG-1X and CMG-5X groups (n = 8 per group), and respectively administered 0, 5, or 25 mg/kg/day of CMG extract orally for four weeks. HPLC-ESI-MS/MS results showed that the major compound in CMG extract is ginsenoside Ro. CMG extract significantly increased muscle weight and relative muscle weight (%). CMG extract supplementation dose-dependently increased grip strength (p < 0.0001) and endurance swimming time, decreased levels of serum lactate (p < 0.0001), ammonia (p < 0.0001), creatine kinase (CK) (p = 0.0002), and blood urea nitrogen (p < 0.0001), and economized glucose levels (p < 0.0001) after acute exercise challenge. The glycogen in the gastrocnemius muscle was significantly increased with CMG extract treatment. Biochemical profile results showed that creatinine and triacylglycerol significantly decreased and total protein and glucose increased with CMG treatment. This is the first report that CMG extract supplementation increases muscle mass, improves exercise performance and energy utilization, and decreases fatigue-associated parameters in vivo. The major component of CMG extract is ginsenoside Ro, which could be a potential bioactive compound for use as an ergogenic aid ingredient by the food industry.
Keywords：ginsenoside; Ro; exercise performance; anti-fatigue; muscle mass
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